Rewiring mitochondrial metabolism to counteract exhaustion of CAR-T cells

Rewiring mitochondrial metabolism to counteract exhaustion of CAR-T cells

Blog Article

Abstract Short persistence and early exhaustion of T cells are major limits to the efficacy and broad application of immunotherapy.Exhausted T and chimeric antigen receptor (CAR)-T cells Faraday Bag upregulate expression of genes associated with terminated T cell differentiation, aerobic glycolysis and apoptosis.Among cell exhaustion characteristics, impaired mitochondrial function and dynamics are considered hallmarks.Here, we review the mitochondrial characteristics of exhausted T cells and particularly discuss different aspects of mitochondrial metabolism and plasticity.Furthermore, we propose a novel strategy of rewiring Wellness Formula mitochondrial metabolism to emancipate T cells from exhaustion and of targeting mitochondrial plasticity to boost CAR-T cell therapy efficacy.